2M.D. Asistant, Canakkale Onsekiz Mart University School of Medicine, Department of Ophthalmology, Canakkale/TURKEY
3M.D. Asistant Professor, Canakkale Onsekiz Mart University School of Medicine, Department of Family Medicine, Canakkale/TURKEY Purpose: To evaluate the neutrophil-lymphocyte ratio (NLR) in patients with primary open angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEG).
Material and Methods: A total 120 subjects consisted of 40 POAG patients (Group 1), 40 PEG patients (Group 2), and 40 age and sex matched non-glaucoma subjects (Group 3) were included in this retrospective study. The NLR calculation was made according to division of neutrophil numbers to lymphocyte numbers that were obtained from medical records of the subjects. The correlation between NLR and retinal nerve fiber layer (RNFL) thickness was also evaluated in all groups.
Results: The mean NLR values in Group 1, Group 2, and Group 3 was respectively as 2.3±0.2, 2.9±0.3, and 1.7±0. A significant difference was determined between Group 1 and Group 3 (p=0.012), also between Group 2 and Group 3 (p=0.001), with regard to mean NLR value. However, no significant difference was determined between Group 1 and Group 2 in mean NLR value (p=0.1). Additionally NLR was not found to be correlated with thinning in the RNFL.
Conclusions: The high NLR ratio may likely support the role of oxidative stress and inflammation in the development of glaucoma, especially in PEG patients.
Keywords : Glaucoma; neutrophil-lymphocyte ratio