2M.D., Batman State Hospital, Eye Clinic, Batman/TURKEY
3M.D. Professor, Rececep Tayyip Erdogan University, Faculty of Medicine, Department of Ophthalmology, Rize/TURKEY Purpose: To compare the efficacies of fixed combination dorzolamide-timolol (FCDT) and fixed combination brimonidine-timolol (FCBT) for preventing intraocular pressure (IOP) spikes after phacoemulsification surgery.
Materials and Methods: One hundred and fifty eyes of 150 patients undergoing phacoemulsification surgery were enrolled in this study. Patients were randomly divided preoperatively into three groups according to the drug that instilled immediately after surgery; FCDT group that receiving one drop of FCDT, FCBT group that receiving one drop of FCBT and control group that receiving one drop of artificial tear. IOP was recorded immediately before surgery (baseline), at the 6th hour, 24th hour and 7th day postoperatively.
Results: Mean IOP levels were significantly lower in the treatment groups than in the control group at the 6th and 24th hours (both p<0.001) after surgery whereas there was no significant difference between the treatment groups during the follow-up period.
Conclusion: Our study has demonstrated that both FCDT and FCBT, each one drop administered immediately after procedure, were effective and both had similar efficacy for preventing IOP elevation after phacoemulsification surgery.
Keywords : Dorzolamide-timolol, brimonidine-timolol, intraocular pressure elevation, phacoemulsification