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¹M.D., Ulucanlar Training and Research Hospital, 2^nd Eye Clinic, Ankara/TURKEY
²M.D., Hacettepe University Faculty of Medicine, Department of Biostatistics, Ankara/TURKEY
³M.D. Professor, Ulucanlar Training and Research Hospital, 2^nd Eye Clinic, Ankara/TURKEY Purpose: To compare the discriminating ability of the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) parameters in ocular hypertension (OHT), glaucoma suspect (GS) and primary open angle glaucoma (POAG).
Materials and Methods: Two hundred and nine subjects (62 with OHT, 65 with GS, 82 POAG) were studied retrospectively. ONH configuration was analyzed by Heidelberg Retinal Tomograph III (HRTIII ), RNFL was analyzed by Spectralis Optical Coherence Tomography (SD-OCT). Global and sectoral (temporal, superotemporal, superonasal, nasal, inferonasal, and inferotemporal) optic disc and RNFL parameters were evaluated. The areas under the receiver operator characteristic curve (AUC) were calculated for each HRTIII and SD-OCT parameter to compare the discriminating ability of each imaging method to differentiate between OHT, GS, POAG eyes. Agreement between Moorfields regression analysis (MRA) of HRT and global RNFL categorical classification of SD-OCT was also investigated.
Results: The global rim area (AUC:0.725) and the inferotemporal RNFL thickness (AUC:0.700) demonstrated the best diagnostic performance to discriminate OHT from POAG patients for the HRTIII and SD-OCT respectively. Regarding AUCs distinguishing GS from POAG eyes, both HRT III and SD-OCT parameters had a suboptimal performance. No agreement was found between the MRA classification of HRTIII and global classification of SD-OCT RNFL analysis.
Conclusions: This study demonstrated fairly good performance of the SD-OCT and HRTIII in discriminating eyes with OHT and glaucoma. Although the performance of the RNFL assessment seems to be better than the optic disc assessment, however, both methods performed less well for discriminating the glaucoma from suspected glaucoma. Keywords : Glaucoma, ocular hypertension, glaucoma suspect, optic disc, retinal nerve fiber layer