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Doç. Dr., Sağlık Bilimleri Üniversitesi Gülhane Tıp Fakültesi, Göz Hast. AD Glaucoma, the second most common cause of blindness in the world, results from loss of retinal ganglion cells. Lamina cribrosa has been implicated as the presumed site of axonal damage in glaucoma. It is thought that unmyelinated RGC axons are supported structurally by lamina cribrosa. Deformation of the lamina cribrosa has been suggested to promote glaucomatous optic neuropathy by impeding axoplasmic fl ow within the optic nerve fi bres which causes apoptosis of retinal ganglion cells. Even though structural changes to the lamina cribrosa were evaluated largely by histopathology in glaucoma, until recently, the ability to visualize the lamina cribrosa in vivo has been limited. Recent advancements in optical coherence tomography, including enhanced depth and swept-source imaging, have improved imaging of deeper ocular layers. Posterior laminar displacement, focal laminar defects and altered thickness of lamina cribrosa are associated with glaucomatous structural and functional changes in living human eyes. Imaging of lamina cribrosa may contribute to a better understanding of glaucoma pathogenesis and quantitative measurement of laminar structures may help to diagnose and manage of glaucoma as a potential biomarker. Keywords : Glaucoma, lamina cribrosa, optical coherence tomography