2M.d. Asistant Professor, Duzce University Faculty of Medicine, Department of Ophthalmology, Duzce/TURKEY
3M.D. Associate Professor, Ulucanlar Eye Training and Research Hospital, Ankara/TURKEY Purpose: Central corneal thickness (CCT) is one of the most important prognostic factor for glaucoma. This study was performed to evaluate the relationship between CCT and topographic parameters of the optic nerve head (ONH) obtained with confocal scanning laser ophthalmoscopy in patients with primary open angle glaucoma (POAG).
Material and Methods: One hundred and sixty patients with POAG were included in the study. All of the patients were underwent complete ophthalmic examination. Central corneal thickness was measured with ultrasound pachymeter. Confocal scanning laser ophthalmoscopy was performed on all patients to obtain topographic parameters of the ONH. Sperman correlation analysis was used to evaluate relationship between CCT and topographic parameters of the ONH. Comparison of the parameters in terms of age and sex were done with Mann-Whitney U test .
Results: There were 90 females (%56), and 70 males (%44) with a mean age of 53.03±15.66 years. Mean CCT was 562.38±37.63 mm and mean intraocular pressure was 18.3±3.7 mmHg. There was a negative correlation between age and CCT (r=-0,189; p=0,043). Negative corelation was found between CCT, cup area (CA), (r=-0.327, p<0.001), cup volume (CV) (r=-0,263,p=0.001), cup disc area ratio (CDAR) (r=0.346, p<0.001), linear cup disc ratio (LCDR), (r=-0.358, p<0.001). There was an insignificant negativecorrelation between CCT and mean cup depth. Positive correlation was determined between CCT, rim area (RA) (r=0.257, p=0.001), rim volume (RV), (r=0.324, p<0.001), mean retinal nerve fiber layer thickness (RNFLT) (r=0.295, p<0.001) and nerve fiber layer cross sectional area (RNFL CSA), (r=0.276, p=0.001).
Conclusion: We found positive correlation between CCT and RA, RV, mean RNFLT and negative correlation between CCT and , CA, CV, CDAR and LCDR in patients with POAG. These data were supported that CCT is one of the important prognostic factors for glaucoma.
Keywords : Central corneal thickness, glaucoma, confocal scanning laser ophthalmoscopy, optic nerve head