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¹Kastamonu Devlet Hastanesi, Göz Hastalıkları, Kastamonu, Uzm. Dr.
²Süleyman Demirel Üniversitesi Tıp Fakültesi, Göz Hast. A.D., Isparta, Prof. Dr.
³Süleyman Demirel Üniversitesi Tıp Fakültesi, Göz Hast. A.D., Isparta, Yard. Doç. Dr. Purpose: To investigate effects of topical latanoprost (0.005%) on tear film.
Material and Methods: 20 eyes of 20 patients who had been diagnosed as primary open angle glaucoma and undergone anti-glaucoma treatment, were included in this study. Basal Schirmer test, tear break-up time, Rose Bengal, and ocular surface disease index were applied for all of the cases before topical latanoprost therapy. All of the tests were repeated in 1st, 2nd and 3rd month of the treatment. All results were evaluated with nonparametric Wilcoxon test by SPSS 13.0.
Results: Mean age was 51.8±6.4 (SD) (12\8 Female\Male). Mean scores were established as Schirmer 9.5±3.3 mm, tear break-up time 12.4±3 sec, Rose Bengal 3.85±2, ocular surface disease index 49.53±20 before the terapy. There's no significant changes in Schirmer, Rose Bengal and ocular surface disease index score in 1st, 2nd and 3rd month of the treatment but a significant increase was observed in tear break-up time 13.6±2 (p=0.007) at the 2nd and 13.9±1.8 (p=0.004) 3rd month.
Conclusion: Topical latanoprost (0.005%) may increase tear break-up time in short term use. Keywords : Latanoprost, goblet cell, tear break-up time