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Dokuz Eylül Üniversitesi Tıp Fakültesi, Göz Hastalıkları A.D., İzmir A new group of drugs very similar to prostaglandins in structure, namely ocular hypotensıve lipids have recently gained popularity in the current medical treatment of glaucoma. Ocular hypotensive lipids include prostagtandin analogues and prostamides. Prostaglandin analogues are derivatives of prostaglandin F2α. They increase uveoscleral outflow and can decrease the intraocular pressure up to 50%. The prostaglandin analogues used in current glaucoma therapy are latanoprost, unoprostone and travoprost. The only prostamide is bimatoprost. These drugs not only have similar structure and mechanism of action but also cause similar side effects. They provide similar decreases in the intraocular pressure except for unoprostone. Conjunctival hyperemia, periocular skin color changes, increase in the number and length of lashes are frequently reported. Cystoid macular edema and activation of herpetic keratitis are some serious side effects encountered in selected patients. Keywords : Glaucoma, prostaglandin analogues, ocular hypotensive lipids