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¹Fatih Üniversitesi Hastanesi Göz Hastalıkları A.D., Ankara, Uzm. Dr.
²Fatih Üniversitesi Hastanesi Nefroloji A.D., Ankara, Uzm. Dr.
³Fatih Üniversitesi Hastanesi Göz Hastalıkları A.D., Ankara, Prof. Dr. Purpose: To investigate the effects of lowering serum uric acid levels of hyperuricemia patients with allopurinol on ocular parameters associated with glaucoma.
Materials and Methods: 33 patients with hyperuricemia were assigned to oral allopurinol treatment for 3 months. Before the treatment with allopurinol and at the end of 3rd month of the treatment, all the patients underwent blood uric acid determination and intraocular pressure measurement with Goldman applanation tonometry, visual field examination, mean retinal nerve fiber layer thickness and central corneal thickness measurements.
Results: Mean uric acid level decreased to 5.27±1.58 mg/dl from pretreatment value of 7.60±0.53 mg/dl with allopurinol therapy at the end of 3rd month (p<0.001). There were no statistically significant changes in mean deviation, nerve fiber layer thickness, manifest refraction, central corneal thickness and intraocular pressure values after hyperuricemia treatment (p>0.05). Only pattern standard deviation value significantly decreased (p=0.02). However, with Pearson’s correlation test, there was no correlation between change of uric acid levels and other measured parameters.
Conclusion: Decreasing plasma uric acid concentrations with allopurinol therapy in hyperuricemic patients did not have significant effects on IOP, visual field, nerve fiber layer and central corneal thickness in a short term basis. Role of hyperuricemia in glaucoma pathogenesis seems to be controversial. Keywords : Uric acid, intraocular pressure, glaucoma, allopurinol, corneal thickness